flash cards

High Yield-thyroid thyroidism

Question Answer
How much more potent/active is T3 compared to T4? T3 is 5x more active
Hypothyroidism? ^ TSH, v T4
Hashimoto's Thyroiditis? hypothyroidism caused by immune system attacking thyroid gland
Myxedema Coma? hypothyroidism that causes altered mental status, MODS
Myxedema Coma treatment? ABC, dextrose if hypoglycemic, vasopressors, glucocorticoid, IV T4
IV levothyroxine T4 dose for myxedema coma? IV levothyroxine 4mcg/kg x 1, then 50mcg daily
IV liothyronine T3 dose for myxedema coma? IV liothyronine 10mcg IV q8h
Normal TSH level? 0.4-4 mlU/L
Normal total T4? 4.5-12.5 mcg/dL
Normal free T4? 0.8-1.8 mcg/dL
Treatment of Hyperthyroidism? Methimazole or propylthiouracil (PTU)
How do SSKI, Lugol's solution, lithium carbonate treat Thyroid Storm? they inhibit thyroid hormone secretion
How does propranolol work in Thyroid storm? Inhibits peripheral T4 to T3 conversion
Thyroid Storm? low TSH, high T4
What is Grave's disease? high T4; autoimmune disease; antibody stimulates thyroid glands to make lots of T3 and T4
Does amiodarone have iodine? Yes, about 37% is iodine
How to treat Amiodarone Induced Thyrotoxicosis (AIT)? methimazole and/or steroids
What rare severe side effect is caused by using methimazole or propylthiouracil? agranulocytosis
Thyroid Storm treatment? O2, APAP, IVF, methimazole or PTU, then SSKI or Lugol's solution
Why do you don't want to give aspirin in Thyroid Storm? ASA displaces T4 from albumin

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